L_Kynurenine_simple_molecule -> AHR_L_KYN_complex
AHR -> AHR_L_KYN_complex
CO_simple_molecule -| Nf_KB_Complex_complex
Heme_simple_molecule -> IDO1_complex
IDO1 -> IDO1_complex
L_Tryptophan_simple_molecule_default_compartment -> L_Tryptophan_simple_molecule_Cytosol
SLC36A4 -> L_Tryptophan_simple_molecule_Cytosol
IDO1_rna -> IDO1
L_Tryptophan_simple_molecule_Cytosol -> NFK_simple_molecule
sa4_O2_simple_molecule_Cytosol -> NFK_simple_molecule
IDO2 -> NFK_simple_molecule
IDO1_complex -> NFK_simple_molecule
Epacadostat_drug -| NFK_simple_molecule
L_Kynurenine_simple_molecule -> AP_DOBu_simple_molecule
PYR_simple_molecule -> AP_DOBu_simple_molecule
PXLP_KYAT1_complex -> AP_DOBu_simple_molecule
I3PROPA -| AP_DOBu_simple_molecule
L_Phe_simple_molecule -| AP_DOBu_simple_molecule
I3LACT -| AP_DOBu_simple_molecule
NFK_simple_molecule -> HCOOH_simple_molecule
sa10_H2O_simple_molecule_Cytosol -> HCOOH_simple_molecule
AFMID -> HCOOH_simple_molecule
NFK_simple_molecule -> L_Kynurenine_simple_molecule
sa10_H2O_simple_molecule_Cytosol -> L_Kynurenine_simple_molecule
AFMID -> L_Kynurenine_simple_molecule
L_Kynurenine_simple_molecule -> sa21_H2O_simple_molecule_Cytosol
sa22_O2_simple_molecule_Cytosol -> sa21_H2O_simple_molecule_Cytosol
sa24_NADPH_simple_molecule_Cytosol -> sa21_H2O_simple_molecule_Cytosol
sa25_H__ion_Cytosol -> sa21_H2O_simple_molecule_Cytosol
KMO -> sa21_H2O_simple_molecule_Cytosol
L_Kynurenine_simple_molecule -> sa23_NADP__simple_molecule_Cytosol
sa22_O2_simple_molecule_Cytosol -> sa23_NADP__simple_molecule_Cytosol
sa24_NADPH_simple_molecule_Cytosol -> sa23_NADP__simple_molecule_Cytosol
sa25_H__ion_Cytosol -> sa23_NADP__simple_molecule_Cytosol
KMO -> sa23_NADP__simple_molecule_Cytosol
AP_DOBu_simple_molecule -> sa27_H2O_simple_molecule_Cytosol
AP_DOBu_simple_molecule -> KYNA_simple_molecule
L_Kynurenine_simple_molecule -> L_Ala_simple_molecule
PYR_simple_molecule -> L_Ala_simple_molecule
PXLP_KYAT1_complex -> L_Ala_simple_molecule
I3PROPA -| L_Ala_simple_molecule
L_Phe_simple_molecule -| L_Ala_simple_molecule
I3LACT -| L_Ala_simple_molecule
CCBL2 -> L_Ala_simple_molecule
3HKYN_simple_molecule -> L_Ala_simple_molecule
sa33_H2O_simple_molecule_Cytosol -> L_Ala_simple_molecule
KYNU -> L_Ala_simple_molecule
3HKYN_simple_molecule -> 3HAA_simple_molecule
sa33_H2O_simple_molecule_Cytosol -> 3HAA_simple_molecule
KYNU -> 3HAA_simple_molecule
L_Kynurenine_simple_molecule -> 3HKYN_simple_molecule
sa22_O2_simple_molecule_Cytosol -> 3HKYN_simple_molecule
sa24_NADPH_simple_molecule_Cytosol -> 3HKYN_simple_molecule
sa25_H__ion_Cytosol -> 3HKYN_simple_molecule
KMO -> 3HKYN_simple_molecule
3HAA_simple_molecule -> Regulatory_T_cell_generation_phenotype
AHR_L_KYN_complex -> Regulatory_T_cell_generation_phenotype
ACS_simple_molecule -> sa36_H2O_simple_molecule_Cytosol
3HAA_simple_molecule -> ACS_simple_molecule
sa39_O2_simple_molecule_Cytosol -> ACS_simple_molecule
HAAO -> ACS_simple_molecule
ACS_simple_molecule -> sa40_CO2_simple_molecule_Cytosol
ACMSD -> sa40_CO2_simple_molecule_Cytosol
ACS_simple_molecule -> QUIN_simple_molecule
2AMA_simple_molecule -> sa43_H__ion_Cytosol
sa46_H2O_simple_molecule_Cytosol -> sa43_H__ion_Cytosol
sa45_NAD__simple_molecule_Cytosol -> sa43_H__ion_Cytosol
2AMA_simple_molecule -> NADH_simple_molecule_Cytosol
sa46_H2O_simple_molecule_Cytosol -> NADH_simple_molecule_Cytosol
sa45_NAD__simple_molecule_Cytosol -> NADH_simple_molecule_Cytosol
ACS_simple_molecule -> 2AMA_simple_molecule
ACMSD -> 2AMA_simple_molecule
2AMA_simple_molecule -> 2AM_simple_molecule
sa46_H2O_simple_molecule_Cytosol -> 2AM_simple_molecule
sa45_NAD__simple_molecule_Cytosol -> 2AM_simple_molecule
IFN_G -> iNOS_rna
Nf_KB_Complex_complex -> iNOS_rna
CO_simple_molecule -| iNOS_rna
iNOS_rna -> iNOS
L_Arginine_simple_molecule -> NO_simple_molecule
sa379_NADPH_simple_molecule_Cytosol -> NO_simple_molecule
sa383_O2_simple_molecule_Cytosol -> NO_simple_molecule
iNOS -> NO_simple_molecule
NO_simple_molecule -| IDO1_rna
IFN_G -> IDO1_rna
NAMN_simple_molecule_Mitochondrial_Matrix -> PPi__3___simple_molecule
sa94_ATP_simple_molecule_Mitochondrial_Matrix -> PPi__3___simple_molecule
NMNAT3_Mg2__complex -> PPi__3___simple_molecule
NAMN_simple_molecule_Mitochondrial_Matrix -> NAAD_simple_molecule_Mitochondrial_Matrix
sa94_ATP_simple_molecule_Mitochondrial_Matrix -> NAAD_simple_molecule_Mitochondrial_Matrix
NMNAT3_Mg2__complex -> NAAD_simple_molecule_Mitochondrial_Matrix
S_NADPHX_simple_molecule -> H__ion_Mitochondrial_Matrix
sa103_ATP_simple_molecule_Mitochondrial_Matrix -> H__ion_Mitochondrial_Matrix
CARKD -> H__ion_Mitochondrial_Matrix
NAD__simple_molecule_Mitochondrial_Matrix -> H__ion_Mitochondrial_Matrix
sa107_ATP_simple_molecule_Mitochondrial_Matrix -> H__ion_Mitochondrial_Matrix
NADK2 -> H__ion_Mitochondrial_Matrix
S_NADPHX_simple_molecule -> ADP_simple_molecule_Mitochondrial_Matrix
sa103_ATP_simple_molecule_Mitochondrial_Matrix -> ADP_simple_molecule_Mitochondrial_Matrix
CARKD -> ADP_simple_molecule_Mitochondrial_Matrix
NAD__simple_molecule_Mitochondrial_Matrix -> ADP_simple_molecule_Mitochondrial_Matrix
sa107_ATP_simple_molecule_Mitochondrial_Matrix -> ADP_simple_molecule_Mitochondrial_Matrix
NADK2 -> ADP_simple_molecule_Mitochondrial_Matrix
S_NADPHX_simple_molecule -> NADPH_simple_molecule_Mitochondrial_Matrix
sa103_ATP_simple_molecule_Mitochondrial_Matrix -> NADPH_simple_molecule_Mitochondrial_Matrix
CARKD -> NADPH_simple_molecule_Mitochondrial_Matrix
R_NADPHX_simple_molecule -> S_NADPHX_simple_molecule
APOA1BP -> S_NADPHX_simple_molecule
NAD__simple_molecule_Mitochondrial_Matrix -> NADP__simple_molecule_Mitochondrial_Matrix
sa107_ATP_simple_molecule_Mitochondrial_Matrix -> NADP__simple_molecule_Mitochondrial_Matrix
NADK2 -> NADP__simple_molecule_Mitochondrial_Matrix
S_NADPHX_simple_molecule -> Pi_simple_molecule
sa103_ATP_simple_molecule_Mitochondrial_Matrix -> Pi_simple_molecule
CARKD -> Pi_simple_molecule
SLC22A13 -> NCA_simple_molecule
NCA_simple_molecule -> sa192_PPi_simple_molecule_Cytosol
sa187_PRPP_simple_molecule_Cytosol -> sa192_PPi_simple_molecule_Cytosol
sa190_H__ion_Cytosol -> sa192_PPi_simple_molecule_Cytosol
NAPRT1 -> sa192_PPi_simple_molecule_Cytosol
Mg2__ion -> sa192_PPi_simple_molecule_Cytosol
NAM_simple_molecule_Cytosol -> sa193_PPi_simple_molecule_Cytosol
sa210_PRPP_simple_molecule_Cytosol -> sa193_PPi_simple_molecule_Cytosol
NAMPT -> sa193_PPi_simple_molecule_Cytosol
QUIN_simple_molecule -> sa194_H2O_simple_molecule_Cytosol
sa202_PRPP_simple_molecule_Cytosol -> sa194_H2O_simple_molecule_Cytosol
sa195_H__ion_Cytosol -> sa194_H2O_simple_molecule_Cytosol
QPRT -> sa194_H2O_simple_molecule_Cytosol
NAR_simple_molecule -> NAMN_simple_molecule_Cytosol
sa218_ATP_simple_molecule_Cytosol -> NAMN_simple_molecule_Cytosol
NMRK1 -> NAMN_simple_molecule_Cytosol
sa215_NMRK2_Cytosol -> NAMN_simple_molecule_Cytosol
NCA_simple_molecule -> NAMN_simple_molecule_Cytosol
sa187_PRPP_simple_molecule_Cytosol -> NAMN_simple_molecule_Cytosol
sa190_H__ion_Cytosol -> NAMN_simple_molecule_Cytosol
NAPRT1 -> NAMN_simple_molecule_Cytosol
Mg2__ion -> NAMN_simple_molecule_Cytosol
NAM_simple_molecule_Cytosol -> NAMN_simple_molecule_Cytosol
sa210_PRPP_simple_molecule_Cytosol -> NAMN_simple_molecule_Cytosol
NAMPT -> NAMN_simple_molecule_Cytosol
QUIN_simple_molecule -> NAMN_simple_molecule_Cytosol
sa202_PRPP_simple_molecule_Cytosol -> NAMN_simple_molecule_Cytosol
sa195_H__ion_Cytosol -> NAMN_simple_molecule_Cytosol
QPRT -> NAMN_simple_molecule_Cytosol
NAMN_simple_molecule_Cytosol -> NAAD_simple_molecule_Cytosol
NMNAT2_Mg2__complex -> NAAD_simple_molecule_Cytosol
QUIN_simple_molecule -> sa201_CO2_simple_molecule_Cytosol
sa202_PRPP_simple_molecule_Cytosol -> sa201_CO2_simple_molecule_Cytosol
sa195_H__ion_Cytosol -> sa201_CO2_simple_molecule_Cytosol
QPRT -> sa201_CO2_simple_molecule_Cytosol
NAMN_simple_molecule_Cytosol -> sa203_PPi_3___simple_molecule_Cytosol
NMNAT2_Mg2__complex -> sa203_PPi_3___simple_molecule_Cytosol
NAAD_simple_molecule_Cytosol -> sa211_PPi_simple_molecule_Cytosol
sa204_ATP_simple_molecule_Cytosol -> sa211_PPi_simple_molecule_Cytosol
L_Gln_simple_molecule -> sa211_PPi_simple_molecule_Cytosol
sa205_H2O_simple_molecule_Cytosol -> sa211_PPi_simple_molecule_Cytosol
NADSYN1 -> sa211_PPi_simple_molecule_Cytosol
NAAD_simple_molecule_Cytosol -> L_Glu_simple_molecule
sa204_ATP_simple_molecule_Cytosol -> L_Glu_simple_molecule
L_Gln_simple_molecule -> L_Glu_simple_molecule
sa205_H2O_simple_molecule_Cytosol -> L_Glu_simple_molecule
NADSYN1 -> L_Glu_simple_molecule
NAAD_simple_molecule_Cytosol -> AMP_simple_molecule_Cytosol
sa204_ATP_simple_molecule_Cytosol -> AMP_simple_molecule_Cytosol
L_Gln_simple_molecule -> AMP_simple_molecule_Cytosol
sa205_H2O_simple_molecule_Cytosol -> AMP_simple_molecule_Cytosol
NADSYN1 -> AMP_simple_molecule_Cytosol
NR_simple_molecule -> sa217_ADP_simple_molecule_Cytosol
sa239_ATP_simple_molecule_Cytosol -> sa217_ADP_simple_molecule_Cytosol
NMRK1 -> sa217_ADP_simple_molecule_Cytosol
sa237_NMRK2_Cytosol -> sa217_ADP_simple_molecule_Cytosol
NAR_simple_molecule -> sa219_H__ion_Cytosol
sa218_ATP_simple_molecule_Cytosol -> sa219_H__ion_Cytosol
NMRK1 -> sa219_H__ion_Cytosol
sa215_NMRK2_Cytosol -> sa219_H__ion_Cytosol
NAM_simple_molecule_Cytosol -> MNA_simple_molecule
AdoMet_simple_molecule -> MNA_simple_molecule
NNMT -> MNA_simple_molecule
sa222_NAD__simple_molecule_Cytosol -> NAM_simple_molecule_Cytosol
_ADP_D_ribosyl__n__acceptor_simple_molecule -> NAM_simple_molecule_Cytosol
PARPs -> NAM_simple_molecule_Cytosol
NAAD_simple_molecule_Cytosol -> sa222_NAD__simple_molecule_Cytosol
sa204_ATP_simple_molecule_Cytosol -> sa222_NAD__simple_molecule_Cytosol
L_Gln_simple_molecule -> sa222_NAD__simple_molecule_Cytosol
sa205_H2O_simple_molecule_Cytosol -> sa222_NAD__simple_molecule_Cytosol
NADSYN1 -> sa222_NAD__simple_molecule_Cytosol
NMN_simple_molecule_Cytosol -> sa222_NAD__simple_molecule_Cytosol
sa229_ATP_simple_molecule_Cytosol -> sa222_NAD__simple_molecule_Cytosol
NMNAT2_Mg2__complex -> sa222_NAD__simple_molecule_Cytosol
NR_simple_molecule -> NMN_simple_molecule_Cytosol
sa239_ATP_simple_molecule_Cytosol -> NMN_simple_molecule_Cytosol
NMRK1 -> NMN_simple_molecule_Cytosol
sa237_NMRK2_Cytosol -> NMN_simple_molecule_Cytosol
NAR_simple_molecule -> sa226_ADP_simple_molecule_Cytosol
sa218_ATP_simple_molecule_Cytosol -> sa226_ADP_simple_molecule_Cytosol
NMRK1 -> sa226_ADP_simple_molecule_Cytosol
sa215_NMRK2_Cytosol -> sa226_ADP_simple_molecule_Cytosol
NMN_simple_molecule_Cytosol -> sa228_PPi_3___simple_molecule_Cytosol
sa229_ATP_simple_molecule_Cytosol -> sa228_PPi_3___simple_molecule_Cytosol
NMNAT2_Mg2__complex -> sa228_PPi_3___simple_molecule_Cytosol
NAM_simple_molecule_Cytosol -> AdoHcy_simple_molecule
AdoMet_simple_molecule -> AdoHcy_simple_molecule
NNMT -> AdoHcy_simple_molecule
sa222_NAD__simple_molecule_Cytosol -> _ADP_D_ribosyl__n_1__acceptor_simple_molecule
_ADP_D_ribosyl__n__acceptor_simple_molecule -> _ADP_D_ribosyl__n_1__acceptor_simple_molecule
PARPs -> _ADP_D_ribosyl__n_1__acceptor_simple_molecule
NR_simple_molecule -> sa235_H__ion_Cytosol
sa239_ATP_simple_molecule_Cytosol -> sa235_H__ion_Cytosol
NMRK1 -> sa235_H__ion_Cytosol
sa237_NMRK2_Cytosol -> sa235_H__ion_Cytosol
sa222_NAD__simple_molecule_Cytosol -> sa240_ADP_simple_molecule_Cytosol
sa227_ATP_simple_molecule_Cytosol -> sa240_ADP_simple_molecule_Cytosol
NADK_Zn2__tetramer_complex -> sa240_ADP_simple_molecule_Cytosol
sa222_NAD__simple_molecule_Cytosol -> sa241_NADP__simple_molecule_Cytosol
sa227_ATP_simple_molecule_Cytosol -> sa241_NADP__simple_molecule_Cytosol
NADK_Zn2__tetramer_complex -> sa241_NADP__simple_molecule_Cytosol
NAD__simple_molecule_default_compartment -> sa252_H__ion_default_compartment
sa255_H2O_simple_molecule_default_compartment -> sa252_H__ion_default_compartment
BST1 -> sa252_H__ion_default_compartment
CD38 -> sa252_H__ion_default_compartment
NAD__simple_molecule_default_compartment -> NAM_simple_molecule_default_compartment
sa255_H2O_simple_molecule_default_compartment -> NAM_simple_molecule_default_compartment
BST1 -> NAM_simple_molecule_default_compartment
CD38 -> NAM_simple_molecule_default_compartment
dh_beta_NAD_simple_molecule -> H2O2_simple_molecule
O2_ion -> H2O2_simple_molecule
sa251_H__ion_default_compartment -> H2O2_simple_molecule
RNLS_FAD_complex -> H2O2_simple_molecule
dh_beta_NAD_simple_molecule -> NAD__simple_molecule_default_compartment
O2_ion -> NAD__simple_molecule_default_compartment
sa251_H__ion_default_compartment -> NAD__simple_molecule_default_compartment
RNLS_FAD_complex -> NAD__simple_molecule_default_compartment
NAD__simple_molecule_default_compartment -> ADP_ribose_simple_molecule
sa255_H2O_simple_molecule_default_compartment -> ADP_ribose_simple_molecule
BST1 -> ADP_ribose_simple_molecule
CD38 -> ADP_ribose_simple_molecule
NAD__simple_molecule_default_compartment -> sa259_Pi_ion_default_compartment
sa257_H2O_simple_molecule_default_compartment -> sa259_Pi_ion_default_compartment
NT5E_Zn2__complex -> sa259_Pi_ion_default_compartment
NAD__simple_molecule_default_compartment -> NMN_simple_molecule_default_compartment
sa257_H2O_simple_molecule_default_compartment -> NMN_simple_molecule_default_compartment
NT5E_Zn2__complex -> NMN_simple_molecule_default_compartment
NMN_simple_molecule_default_compartment -> sa262_Pi_ion_default_compartment
sa261_H2O_simple_molecule_default_compartment -> sa262_Pi_ion_default_compartment
NT5E_Zn2__complex -> sa262_Pi_ion_default_compartment
NMN_simple_molecule_default_compartment -> NRNAM_simple_molecule
sa261_H2O_simple_molecule_default_compartment -> NRNAM_simple_molecule
NT5E_Zn2__complex -> NRNAM_simple_molecule
NADH_simple_molecule_Peroxisomal_Matrix -> NMNH_simple_molecule
AMP_simple_molecule_Peroxisomal_Matrix -> NMNH_simple_molecule
H2O_simple_molecule_Peroxisomal_Matrix -> NMNH_simple_molecule
NUDT12 -> NMNH_simple_molecule
NADH_simple_molecule_Peroxisomal_Matrix -> H__ion_Peroxisomal_Matrix
AMP_simple_molecule_Peroxisomal_Matrix -> H__ion_Peroxisomal_Matrix
H2O_simple_molecule_Peroxisomal_Matrix -> H__ion_Peroxisomal_Matrix
NUDT12 -> H__ion_Peroxisomal_Matrix
NAMN_simple_molecule_Nucleoplasm -> NAAD_simple_molecule_Nucleoplasm
ATP_simple_molecule_Nucleoplasm -> NAAD_simple_molecule_Nucleoplasm
NMNAT1_Zn2__complex -> NAAD_simple_molecule_Nucleoplasm
NAMN_simple_molecule_Nucleoplasm -> PPi_3___simple_molecule_Nucleoplasm
ATP_simple_molecule_Nucleoplasm -> PPi_3___simple_molecule_Nucleoplasm
NMNAT1_Zn2__complex -> PPi_3___simple_molecule_Nucleoplasm
PGH2_simple_molecule -> PGI2_simple_molecule
PTGIS -> PGI2_simple_molecule
PGG2_simple_molecule -> PGH2_simple_molecule
e__ion -> PGH2_simple_molecule
H__ion_ER_Lumen -> PGH2_simple_molecule
PTGS2 -> PGH2_simple_molecule
PTCS2_celecoxib_complex -| PGH2_simple_molecule
MNA_simple_molecule -> PGH2_simple_molecule
PGG2_simple_molecule -> H2O_simple_molecule_ER_Lumen
e__ion -> H2O_simple_molecule_ER_Lumen
H__ion_ER_Lumen -> H2O_simple_molecule_ER_Lumen
PTGS2 -> H2O_simple_molecule_ER_Lumen
PTCS2_celecoxib_complex -| H2O_simple_molecule_ER_Lumen
MNA_simple_molecule -> H2O_simple_molecule_ER_Lumen
monocarboxylates_transported_by_SLC5A8_simple_molecule_default_compartment -> monocarboxylates_transported_by_SLC5A8_simple_molecule_Cytosol
Na__ion_default_compartment -> monocarboxylates_transported_by_SLC5A8_simple_molecule_Cytosol
SLC5A8 -> monocarboxylates_transported_by_SLC5A8_simple_molecule_Cytosol
monocarboxylates_transported_by_SLC5A8_simple_molecule_default_compartment -> Na__ion_Cytosol
Na__ion_default_compartment -> Na__ion_Cytosol
SLC5A8 -> Na__ion_Cytosol
IFN_G -> HMOX1_rna
NO_simple_molecule -> HMOX1_rna
3HAA_simple_molecule -> HMOX1_rna
HMOX1_rna -> sa351_HMOX1_Cytosol
sa351_HMOX1_Cytosol -> sa352_HMOX1_Cytosol
Orf3a -> sa352_HMOX1_Cytosol
Heme_simple_molecule -> sa353_H2O_simple_molecule_Cytosol
sa358_O2_simple_molecule_Cytosol -> sa353_H2O_simple_molecule_Cytosol
sa356_NADPH_simple_molecule_Cytosol -> sa353_H2O_simple_molecule_Cytosol
sa352_HMOX1_Cytosol -> sa353_H2O_simple_molecule_Cytosol
Heme_simple_molecule -> sa354_NADP__simple_molecule_Cytosol
sa358_O2_simple_molecule_Cytosol -> sa354_NADP__simple_molecule_Cytosol
sa356_NADPH_simple_molecule_Cytosol -> sa354_NADP__simple_molecule_Cytosol
sa352_HMOX1_Cytosol -> sa354_NADP__simple_molecule_Cytosol
Heme_simple_molecule -> Fe2__ion
sa358_O2_simple_molecule_Cytosol -> Fe2__ion
sa356_NADPH_simple_molecule_Cytosol -> Fe2__ion
sa352_HMOX1_Cytosol -> Fe2__ion
Heme_simple_molecule -> Biliverdin_simple_molecule
sa358_O2_simple_molecule_Cytosol -> Biliverdin_simple_molecule
sa356_NADPH_simple_molecule_Cytosol -> Biliverdin_simple_molecule
sa352_HMOX1_Cytosol -> Biliverdin_simple_molecule
Heme_simple_molecule -> CO_simple_molecule
sa358_O2_simple_molecule_Cytosol -> CO_simple_molecule
sa356_NADPH_simple_molecule_Cytosol -> CO_simple_molecule
sa352_HMOX1_Cytosol -> CO_simple_molecule
L_Tryptophan_simple_molecule_default_compartment -| Effector_T_cell_apoptosis_phenotype
3HAA_simple_molecule -> CA_simple_molecule
3HAA_simple_molecule -| Th1_cell_cytokine_production_phenotype
CA_simple_molecule -> T_cell_apoptosis_phenotype
3HKYN_simple_molecule -> T_cell_apoptosis_phenotype
L_Kynurenine_simple_molecule -> T_cell_apoptosis_phenotype
3HAA_simple_molecule -> T_cell_apoptosis_phenotype
3HAA_simple_molecule -> Dendritic_cell_maturation_phenotype
3HKYN_simple_molecule -> Dendritic_cell_maturation_phenotype
L_Arginine_simple_molecule -> sa380_NADP__simple_molecule_Cytosol
sa379_NADPH_simple_molecule_Cytosol -> sa380_NADP__simple_molecule_Cytosol
sa383_O2_simple_molecule_Cytosol -> sa380_NADP__simple_molecule_Cytosol
iNOS -> sa380_NADP__simple_molecule_Cytosol
L_Arginine_simple_molecule -> sa381_H__ion_Cytosol
sa379_NADPH_simple_molecule_Cytosol -> sa381_H__ion_Cytosol
sa383_O2_simple_molecule_Cytosol -> sa381_H__ion_Cytosol
iNOS -> sa381_H__ion_Cytosol
L_Arginine_simple_molecule -> Citrulline_simple_molecule
sa379_NADPH_simple_molecule_Cytosol -> Citrulline_simple_molecule
sa383_O2_simple_molecule_Cytosol -> Citrulline_simple_molecule
iNOS -> Citrulline_simple_molecule
$2AMA_simple_molecule: (ACS_simple_molecule & ACMSD)
$2AM_simple_molecule: ((2AMA_simple_molecule & sa46_H2O_simple_molecule_Cytosol) & sa45_NAD__simple_molecule_Cytosol)
$3HAA_simple_molecule: ((3HKYN_simple_molecule & sa33_H2O_simple_molecule_Cytosol) & KYNU)
$3HKYN_simple_molecule: ((((L_Kynurenine_simple_molecule & sa22_O2_simple_molecule_Cytosol) & sa24_NADPH_simple_molecule_Cytosol) & sa25_H__ion_Cytosol) & KMO)
$ACS_simple_molecule: ((3HAA_simple_molecule & sa39_O2_simple_molecule_Cytosol) & HAAO)
$ADP_ribose_simple_molecule: (((NAD__simple_molecule_default_compartment & sa255_H2O_simple_molecule_default_compartment) & BST1) | ((NAD__simple_molecule_default_compartment & sa255_H2O_simple_molecule_default_compartment) & CD38))
$ADP_simple_molecule_Mitochondrial_Matrix: (((S_NADPHX_simple_molecule & sa103_ATP_simple_molecule_Mitochondrial_Matrix) & CARKD) | ((NAD__simple_molecule_Mitochondrial_Matrix & sa107_ATP_simple_molecule_Mitochondrial_Matrix) & NADK2))
$AHR_L_KYN_complex: (L_Kynurenine_simple_molecule & AHR)
$AMP_simple_molecule_Cytosol: ((((NAAD_simple_molecule_Cytosol & sa204_ATP_simple_molecule_Cytosol) & L_Gln_simple_molecule) & sa205_H2O_simple_molecule_Cytosol) & NADSYN1)
$AP_DOBu_simple_molecule: (((((L_Kynurenine_simple_molecule & PYR_simple_molecule) & PXLP_KYAT1_complex) & !I3PROPA) & !L_Phe_simple_molecule) & !I3LACT)
$AdoHcy_simple_molecule: ((NAM_simple_molecule_Cytosol & AdoMet_simple_molecule) & NNMT)
$Biliverdin_simple_molecule: (((Heme_simple_molecule & sa358_O2_simple_molecule_Cytosol) & sa356_NADPH_simple_molecule_Cytosol) & sa352_HMOX1_Cytosol)
$CA_simple_molecule: 3HAA_simple_molecule
$CO_simple_molecule: (((Heme_simple_molecule & sa358_O2_simple_molecule_Cytosol) & sa356_NADPH_simple_molecule_Cytosol) & sa352_HMOX1_Cytosol)
$Citrulline_simple_molecule: (((L_Arginine_simple_molecule & sa379_NADPH_simple_molecule_Cytosol) & sa383_O2_simple_molecule_Cytosol) & iNOS)
$Dendritic_cell_maturation_phenotype: (3HAA_simple_molecule & 3HKYN_simple_molecule)
$Effector_T_cell_apoptosis_phenotype: !L_Tryptophan_simple_molecule_default_compartment
$Fe2__ion: (((Heme_simple_molecule & sa358_O2_simple_molecule_Cytosol) & sa356_NADPH_simple_molecule_Cytosol) & sa352_HMOX1_Cytosol)
$H2O2_simple_molecule: (((dh_beta_NAD_simple_molecule & O2_ion) & sa251_H__ion_default_compartment) & RNLS_FAD_complex)
$H2O_simple_molecule_ER_Lumen: (((((PTGS2 | MNA_simple_molecule) & PGG2_simple_molecule) & e__ion) & H__ion_ER_Lumen) & !PTCS2_celecoxib_complex)
$HCOOH_simple_molecule: ((NFK_simple_molecule & sa10_H2O_simple_molecule_Cytosol) & AFMID)
$HMOX1_rna: ((IFN_G | NO_simple_molecule) | 3HAA_simple_molecule)
$H__ion_Mitochondrial_Matrix: (((S_NADPHX_simple_molecule & sa103_ATP_simple_molecule_Mitochondrial_Matrix) & CARKD) | ((NAD__simple_molecule_Mitochondrial_Matrix & sa107_ATP_simple_molecule_Mitochondrial_Matrix) & NADK2))
$H__ion_Peroxisomal_Matrix: (((NADH_simple_molecule_Peroxisomal_Matrix & AMP_simple_molecule_Peroxisomal_Matrix) & H2O_simple_molecule_Peroxisomal_Matrix) & NUDT12)
$IDO1: IDO1_rna
$IDO1_complex: (Heme_simple_molecule & IDO1)
$IDO1_rna: (IFN_G & !NO_simple_molecule)
$KYNA_simple_molecule: AP_DOBu_simple_molecule
$L_Ala_simple_molecule: (((((((L_Kynurenine_simple_molecule & PYR_simple_molecule) & PXLP_KYAT1_complex) & !I3PROPA) & !L_Phe_simple_molecule) & !I3LACT) | ((L_Kynurenine_simple_molecule & PYR_simple_molecule) & CCBL2)) | ((3HKYN_simple_molecule & sa33_H2O_simple_molecule_Cytosol) & KYNU))
$L_Glu_simple_molecule: ((((NAAD_simple_molecule_Cytosol & sa204_ATP_simple_molecule_Cytosol) & L_Gln_simple_molecule) & sa205_H2O_simple_molecule_Cytosol) & NADSYN1)
$L_Kynurenine_simple_molecule: ((NFK_simple_molecule & sa10_H2O_simple_molecule_Cytosol) & AFMID)
$L_Tryptophan_simple_molecule_Cytosol: (L_Tryptophan_simple_molecule_default_compartment & SLC36A4)
$MNA_simple_molecule: ((NAM_simple_molecule_Cytosol & AdoMet_simple_molecule) & NNMT)
$NAAD_simple_molecule_Cytosol: (NAMN_simple_molecule_Cytosol & NMNAT2_Mg2__complex)
$NAAD_simple_molecule_Mitochondrial_Matrix: ((NAMN_simple_molecule_Mitochondrial_Matrix & sa94_ATP_simple_molecule_Mitochondrial_Matrix) & NMNAT3_Mg2__complex)
$NAAD_simple_molecule_Nucleoplasm: ((NAMN_simple_molecule_Nucleoplasm & ATP_simple_molecule_Nucleoplasm) & NMNAT1_Zn2__complex)
$NADH_simple_molecule_Cytosol: ((2AMA_simple_molecule & sa46_H2O_simple_molecule_Cytosol) & sa45_NAD__simple_molecule_Cytosol)
$NADPH_simple_molecule_Mitochondrial_Matrix: ((S_NADPHX_simple_molecule & sa103_ATP_simple_molecule_Mitochondrial_Matrix) & CARKD)
$NADP__simple_molecule_Mitochondrial_Matrix: ((NAD__simple_molecule_Mitochondrial_Matrix & sa107_ATP_simple_molecule_Mitochondrial_Matrix) & NADK2)
$NAD__simple_molecule_default_compartment: (((dh_beta_NAD_simple_molecule & O2_ion) & sa251_H__ion_default_compartment) & RNLS_FAD_complex)
$NAMN_simple_molecule_Cytosol: ((((((NAR_simple_molecule & sa218_ATP_simple_molecule_Cytosol) & NMRK1) | ((NAR_simple_molecule & sa218_ATP_simple_molecule_Cytosol) & sa215_NMRK2_Cytosol)) | ((((NAPRT1 | Mg2__ion) & NCA_simple_molecule) & sa187_PRPP_simple_molecule_Cytosol) & sa190_H__ion_Cytosol)) | ((NAM_simple_molecule_Cytosol & sa210_PRPP_simple_molecule_Cytosol) & NAMPT)) | (((QUIN_simple_molecule & sa202_PRPP_simple_molecule_Cytosol) & sa195_H__ion_Cytosol) & QPRT))
$NAM_simple_molecule_Cytosol: ((sa222_NAD__simple_molecule_Cytosol & _ADP_D_ribosyl__n__acceptor_simple_molecule) & PARPs)
$NAM_simple_molecule_default_compartment: (((NAD__simple_molecule_default_compartment & sa255_H2O_simple_molecule_default_compartment) & BST1) | ((NAD__simple_molecule_default_compartment & sa255_H2O_simple_molecule_default_compartment) & CD38))
$NCA_simple_molecule: SLC22A13
$NFK_simple_molecule: (((L_Tryptophan_simple_molecule_Cytosol & sa4_O2_simple_molecule_Cytosol) & IDO2) | (((L_Tryptophan_simple_molecule_Cytosol & sa4_O2_simple_molecule_Cytosol) & IDO1_complex) & !Epacadostat_drug))
$NMNH_simple_molecule: (((NADH_simple_molecule_Peroxisomal_Matrix & AMP_simple_molecule_Peroxisomal_Matrix) & H2O_simple_molecule_Peroxisomal_Matrix) & NUDT12)
$NMN_simple_molecule_Cytosol: (((NR_simple_molecule & sa239_ATP_simple_molecule_Cytosol) & NMRK1) | ((NR_simple_molecule & sa239_ATP_simple_molecule_Cytosol) & sa237_NMRK2_Cytosol))
$NMN_simple_molecule_default_compartment: ((NAD__simple_molecule_default_compartment & sa257_H2O_simple_molecule_default_compartment) & NT5E_Zn2__complex)
$NO_simple_molecule: (((L_Arginine_simple_molecule & sa379_NADPH_simple_molecule_Cytosol) & sa383_O2_simple_molecule_Cytosol) & iNOS)
$NRNAM_simple_molecule: ((NMN_simple_molecule_default_compartment & sa261_H2O_simple_molecule_default_compartment) & NT5E_Zn2__complex)
$Na__ion_Cytosol: ((monocarboxylates_transported_by_SLC5A8_simple_molecule_default_compartment & Na__ion_default_compartment) & SLC5A8)
$Nf_KB_Complex_complex: !CO_simple_molecule
$PGH2_simple_molecule: (((((PTGS2 | MNA_simple_molecule) & PGG2_simple_molecule) & e__ion) & H__ion_ER_Lumen) & !PTCS2_celecoxib_complex)
$PGI2_simple_molecule: (PGH2_simple_molecule & PTGIS)
$PPi_3___simple_molecule_Nucleoplasm: ((NAMN_simple_molecule_Nucleoplasm & ATP_simple_molecule_Nucleoplasm) & NMNAT1_Zn2__complex)
$PPi__3___simple_molecule: ((NAMN_simple_molecule_Mitochondrial_Matrix & sa94_ATP_simple_molecule_Mitochondrial_Matrix) & NMNAT3_Mg2__complex)
$Pi_simple_molecule: ((S_NADPHX_simple_molecule & sa103_ATP_simple_molecule_Mitochondrial_Matrix) & CARKD)
$QUIN_simple_molecule: ACS_simple_molecule
$Regulatory_T_cell_generation_phenotype: (3HAA_simple_molecule | AHR_L_KYN_complex)
$S_NADPHX_simple_molecule: (R_NADPHX_simple_molecule & APOA1BP)
$T_cell_apoptosis_phenotype: (CA_simple_molecule | ((3HKYN_simple_molecule & L_Kynurenine_simple_molecule) & 3HAA_simple_molecule))
$Th1_cell_cytokine_production_phenotype: !3HAA_simple_molecule
$_ADP_D_ribosyl__n_1__acceptor_simple_molecule: ((sa222_NAD__simple_molecule_Cytosol & _ADP_D_ribosyl__n__acceptor_simple_molecule) & PARPs)
$iNOS: iNOS_rna
$iNOS_rna: ((IFN_G | Nf_KB_Complex_complex) & !CO_simple_molecule)
$monocarboxylates_transported_by_SLC5A8_simple_molecule_Cytosol: ((monocarboxylates_transported_by_SLC5A8_simple_molecule_default_compartment & Na__ion_default_compartment) & SLC5A8)
$sa192_PPi_simple_molecule_Cytosol: ((((NAPRT1 | Mg2__ion) & NCA_simple_molecule) & sa187_PRPP_simple_molecule_Cytosol) & sa190_H__ion_Cytosol)
$sa193_PPi_simple_molecule_Cytosol: ((NAM_simple_molecule_Cytosol & sa210_PRPP_simple_molecule_Cytosol) & NAMPT)
$sa194_H2O_simple_molecule_Cytosol: (((QUIN_simple_molecule & sa202_PRPP_simple_molecule_Cytosol) & sa195_H__ion_Cytosol) & QPRT)
$sa201_CO2_simple_molecule_Cytosol: (((QUIN_simple_molecule & sa202_PRPP_simple_molecule_Cytosol) & sa195_H__ion_Cytosol) & QPRT)
$sa203_PPi_3___simple_molecule_Cytosol: (NAMN_simple_molecule_Cytosol & NMNAT2_Mg2__complex)
$sa211_PPi_simple_molecule_Cytosol: ((((NAAD_simple_molecule_Cytosol & sa204_ATP_simple_molecule_Cytosol) & L_Gln_simple_molecule) & sa205_H2O_simple_molecule_Cytosol) & NADSYN1)
$sa217_ADP_simple_molecule_Cytosol: (((NR_simple_molecule & sa239_ATP_simple_molecule_Cytosol) & NMRK1) | ((NR_simple_molecule & sa239_ATP_simple_molecule_Cytosol) & sa237_NMRK2_Cytosol))
$sa219_H__ion_Cytosol: (((NAR_simple_molecule & sa218_ATP_simple_molecule_Cytosol) & NMRK1) | ((NAR_simple_molecule & sa218_ATP_simple_molecule_Cytosol) & sa215_NMRK2_Cytosol))
$sa21_H2O_simple_molecule_Cytosol: ((((L_Kynurenine_simple_molecule & sa22_O2_simple_molecule_Cytosol) & sa24_NADPH_simple_molecule_Cytosol) & sa25_H__ion_Cytosol) & KMO)
$sa222_NAD__simple_molecule_Cytosol: (((((NAAD_simple_molecule_Cytosol & sa204_ATP_simple_molecule_Cytosol) & L_Gln_simple_molecule) & sa205_H2O_simple_molecule_Cytosol) & NADSYN1) | ((NMN_simple_molecule_Cytosol & sa229_ATP_simple_molecule_Cytosol) & NMNAT2_Mg2__complex))
$sa226_ADP_simple_molecule_Cytosol: (((NAR_simple_molecule & sa218_ATP_simple_molecule_Cytosol) & NMRK1) | ((NAR_simple_molecule & sa218_ATP_simple_molecule_Cytosol) & sa215_NMRK2_Cytosol))
$sa228_PPi_3___simple_molecule_Cytosol: ((NMN_simple_molecule_Cytosol & sa229_ATP_simple_molecule_Cytosol) & NMNAT2_Mg2__complex)
$sa235_H__ion_Cytosol: (((NR_simple_molecule & sa239_ATP_simple_molecule_Cytosol) & NMRK1) | ((NR_simple_molecule & sa239_ATP_simple_molecule_Cytosol) & sa237_NMRK2_Cytosol))
$sa23_NADP__simple_molecule_Cytosol: ((((L_Kynurenine_simple_molecule & sa22_O2_simple_molecule_Cytosol) & sa24_NADPH_simple_molecule_Cytosol) & sa25_H__ion_Cytosol) & KMO)
$sa240_ADP_simple_molecule_Cytosol: ((sa222_NAD__simple_molecule_Cytosol & sa227_ATP_simple_molecule_Cytosol) & NADK_Zn2__tetramer_complex)
$sa241_NADP__simple_molecule_Cytosol: ((sa222_NAD__simple_molecule_Cytosol & sa227_ATP_simple_molecule_Cytosol) & NADK_Zn2__tetramer_complex)
$sa252_H__ion_default_compartment: (((NAD__simple_molecule_default_compartment & sa255_H2O_simple_molecule_default_compartment) & BST1) | ((NAD__simple_molecule_default_compartment & sa255_H2O_simple_molecule_default_compartment) & CD38))
$sa259_Pi_ion_default_compartment: ((NAD__simple_molecule_default_compartment & sa257_H2O_simple_molecule_default_compartment) & NT5E_Zn2__complex)
$sa262_Pi_ion_default_compartment: ((NMN_simple_molecule_default_compartment & sa261_H2O_simple_molecule_default_compartment) & NT5E_Zn2__complex)
$sa27_H2O_simple_molecule_Cytosol: AP_DOBu_simple_molecule
$sa351_HMOX1_Cytosol: HMOX1_rna
$sa352_HMOX1_Cytosol: (sa351_HMOX1_Cytosol & Orf3a)
$sa353_H2O_simple_molecule_Cytosol: (((Heme_simple_molecule & sa358_O2_simple_molecule_Cytosol) & sa356_NADPH_simple_molecule_Cytosol) & sa352_HMOX1_Cytosol)
$sa354_NADP__simple_molecule_Cytosol: (((Heme_simple_molecule & sa358_O2_simple_molecule_Cytosol) & sa356_NADPH_simple_molecule_Cytosol) & sa352_HMOX1_Cytosol)
$sa36_H2O_simple_molecule_Cytosol: ACS_simple_molecule
$sa380_NADP__simple_molecule_Cytosol: (((L_Arginine_simple_molecule & sa379_NADPH_simple_molecule_Cytosol) & sa383_O2_simple_molecule_Cytosol) & iNOS)
$sa381_H__ion_Cytosol: (((L_Arginine_simple_molecule & sa379_NADPH_simple_molecule_Cytosol) & sa383_O2_simple_molecule_Cytosol) & iNOS)
$sa40_CO2_simple_molecule_Cytosol: (ACS_simple_molecule & ACMSD)
$sa43_H__ion_Cytosol: ((2AMA_simple_molecule & sa46_H2O_simple_molecule_Cytosol) & sa45_NAD__simple_molecule_Cytosol)